Immuno Concepts not only pioneered the conversion from rodent tissue to HEp-2 cells for detection of anti-nuclear antibodies (ANAs), but also overcame one of the main pitfalls of ANA detection with the introduction of HEp-2000®, a patented ANA substrate genetically improved with increased sensitivity for detection of autoantibodies to SS-A/Ro. Over thirty worldwide publications meanwhile confirmed the clinically superior performance of HEp-2000®.